Assessing Gametocyte Carriage in Treated Asymptomatic Falciparum Carriers in Africa
نویسنده
چکیده
Article history: Received 11 November 2016 Accepted 11 November 2016 Available online 15 November 2016 drug studies but it is crucial to realise that gametocytaemia is a weak surrogate marker of mosquito infectivity. Gametocyte density has been shown to correlate withmosquito infectivity in untreated individuals in a non-linear relationship (Jeffery and Eyles, 1955) (Churcher et al., 2012). Post treatment, the relationship is more difficult to define (Beavogui et al., 2010) but Dicko et al. found no relationship following
منابع مشابه
Gametocytaemia after Drug Treatment of Asymptomatic Plasmodium falciparum
OBJECTIVES Treatment of Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a sharp rise in the prevalence and density of gametocytes. We did a randomized trial to determine the effect of treatment of asymptomatic infections with SP or SP plus one dose of artesunate (SP+AS) on gametocyte carriage. DESIGN The study was a three-arm open-label randomized trial. We ra...
متن کاملParasitological Society of Southern Africa
Although eliminating the pathogenic asexual stages of Plasmodium falciparum is pivotal for the successful treatment of individual symptomatic patients, at a population level reducing the carriage of viable gametocytes is crucial for limiting the transmission of malaria parasites. Gametocytes are the non-pathogenic sexual stages of the P. falciparum parasite responsible for transmission of the i...
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